Miguel Molina-Solana

Long non-coding RNAs are known to play multiple roles in the complex machinery of the cell. However, their recent addition to genomic research has increased the complexity of gene expression analyses. In this work, we perform a computational study that aims to contribute to the current understanding of the mechanisms that underlie the experimentally suggested interaction between the lncRNA Fendrr and FoxF1 lung cancer tumor suppressor in carcinogenesis. Results suggest that there exists indeed a multi-level interaction between Fendrr and FoxF1 promoter region, both direct via RNA-DNA:DNA triplex domain formation or mediated by proteins that interact simultaneously with the promoter region of FoxF1 and Fendrr transcripts. Moreover, the applied computational methodology can serve as a pipeline to process any candidate lncRNA-gene pair of interest and obtain putative sources of lncRNA-gene interaction.

@incollection{Navarro2016,
  title = {A Mechanistic Study of lnc{RNA} {F}endrr Regulation of {F}ox{F1} Lung Cancer Tumor Supressor},
  author = {Navarro, Carmen and Cano, Carlos and Cuadros, Marta and Herrera-Merchan, Antonio and Molina, Miguel and Blanco, Armando},
  booktitle = {Bioinformatics and Biomedical Engineering: 4th International Conference, IWBBIO 2016},
  publisher = {Springer International Publishing},
  year = {2016},
  address = {Granada, Spain},
  month = mar,
  pages = {781--789},
  series = {Lecture Notes in Computer Science},
  volume = {9656},
  pdf = {},
  doi = {10.1007/978-3-319-31744-1_67},
  timestamp = {120},
  url = {http://iwbbio.ugr.es/}
}